Article
Androgen receptor modifications in prostate cancer cells upon long-termandrogen ablation and antiandrogen treatment.
International journal of cancer - 1 Nov 2005
Marques Rute B, Erkens-Schulze Sigrun, de Ridder Corrina M, Hermans Karin G, Waltering Kati, Visakorpi Tapio, Trapman Jan, Romijn Johannes C, van Weerden Wytske M, Jenster Guido
Abstract excerpt
To study the mechanisms whereby androgen-dependent tumors relapse in patients undergoing androgen blockade, we developed a novel progression model for prostate cancer. The PC346C cell line, established from a transurethral resection of a primary tumor, expresses wild-type (wt) androgen receptor (AR) and secretes prostate-specific antigen (PSA). Optimal proliferation of PC346C requires androgens and is inhibited...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.