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Article

Adenylate deaminase deficiency in a mutant murine T cell lymphoma cell line.

The Journal of biological chemistry - 15 Jul 1990

Hanson S, McCartan K, Sabina R L, Holmes E W, Ullman B

Abstract excerpt

From a population of wild type S49 cells, a clone, DTB6, was isolated in a single step from selective medium containing thymidine and dibutyryl cyclic AMP that exhibited a 60% deficiency in AMP deaminase (AMP-D) activity. The AMP-D deficiency conferred to the DTB6 cells a striking susceptibility to killing by low concentrations of either adenine or adenosine, the latter in the presence of an inhibitor of...

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PMID: 2365681

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