Article
Adenylate deaminase deficiency in a mutant murine T cell lymphoma cell line.
The Journal of biological chemistry - 15 Jul 1990
Hanson S, McCartan K, Sabina R L, Holmes E W, Ullman B
Abstract excerpt
From a population of wild type S49 cells, a clone, DTB6, was isolated in a single step from selective medium containing thymidine and dibutyryl cyclic AMP that exhibited a 60% deficiency in AMP deaminase (AMP-D) activity. The AMP-D deficiency conferred to the DTB6 cells a striking susceptibility...
Topics
- AMP Deaminase
- Adenine
- Animals
- Blotting, Southern
- Cell Division
- Cell Line
- Cell Survival
- DNA, Neoplasm
- Isoenzymes
- Kinetics
- Lymphoma
- Mice
- Mutation
- Nucleotide Deaminases
- Polyploidy
- Ribonucleotides
- T-Lymphocytes
- Thymidine