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Article

Specific selection of deoxycytidine kinase mutants with tritiated deoxyadenosine.

Biochemical genetics - 1 Oct 1995

Chan T S, Nelson J A

Abstract excerpt

We have shown previously that a low concentration of tritiated deoxyadenosine, i.e., 1 microCi/ml, selectively kills wild-type S49 murine lymphoma cells. Mutant cells resistant to [3H] deoxyadenosine lacked adenosine kinase completely but retained a significant level of deoxyadenosine phosphorylating activity. To study further the specificity of [3H] deoxyadenosine selection, lymphoma cell clones resistant to 15...

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PMID: 8748457
DOI: 10.1007/BF02399931

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