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Two DNA‐binding domains of Mga are required for virulence gene activation in the group A streptococcus

1 Mar 2002

Abstract excerpt

Mga is a DNA-binding protein that activates expression of several important virulence genes in the group A streptococcus (GAS), including those encoding M protein (emm), C5a peptidase (scpA) and Mga (mga). To determine the functionality of four potential helix-turn-helix DNA-binding motifs (HTH1-HTH4) identified within the amino-terminus of Mga, alanine substitutions were introduced within each domain in a...

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PMID: 11952907
DOI: 10.1046/j.1365-2958.2002.02849.x

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