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Article

Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.

Pharmacogenetics and genomics - 1 Jun 2009

Doehring Alexandra, Hentig Nils von, Graff Jochen, Salamat Syavash, Schmidt Michael, Geisslinger Gerd, Harder Sebastian, Lötsch Jörn

Abstract excerpt

AIM: Addictive behavior is importantly mediated by mesolimbic dopaminergic signaling. Here, we comprehensively analyzed the DRD2 gene locus, and in addition, the ANKK1 rs1800497C>T single nucleotide polymorphism (SNP), formerly known as 'dopamine D2 receptor Taq1A C>T polymorphism', for associations with the risk of opiate addiction and the methadone dosage requirements. METHODS: Allelic frequencies of DRD2/ANKK1...

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Source

Identifiers

PMID: 19373123
DOI: 10.1097/FPC.0b013e328320a3fd

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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