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Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant

18 Oct 2007

Abstract excerpt

A human cytomegalovirus (CMV) UL54 pol exonuclease domain II mutation, D413A, found in a clinical specimen, conferred ganciclovir (GCV) and cidofovir resistance but not foscarnet resistance when incorporated into laboratory strain T2294. After several passages without drug, mutation was observed in five of eight plaques of T2294, and its plating efficiency under foscarnet was increased approximately 30-fold over...

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PMID: 17942550
DOI: 10.1128/jvi.01787-07

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