Article
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jul 2014
Ishii Makoto, Wang Gang, Racchumi Gianfranco, Dyke Jonathan P, Iadecola Costantino
Abstract excerpt
Weight loss is a prominent early feature of Alzheimer's disease (AD) that often precedes the cognitive decline and clinical diagnosis. While the exact pathogenesis of AD remains unclear, accumulation of amyloid-β (Aβ) derived from the amyloid precursor protein (APP) in the brain is thought to lea...
Topics
- Adiposity
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Arcuate Nucleus of Hypothalamus
- Brain
- Brain Chemistry
- Disease Models, Animal
- Disease Progression
- Fasting
- Feeding Behavior
- Female