Article
Growth inhibition of Saccharomyces cerevisiae by the immunosuppressant leflunomide is due to the inhibition of uracil uptake via Fur4p.
Molecular & general genetics : MGG - 1 Oct 1998
Fujimura H
Abstract excerpt
The immunosuppressant leflunomide inhibits cytokine-stimulated proliferation of lymphoid cells in vitro and also inhibits the growth of the eukaryotic microorganism Saccharomyces cerevisiae. To elucidate the molecular mechanism of action of the drug, two yeast genes which suppress the anti-prolif...
Topics
- Biological Transport
- Cloning, Molecular
- Fungal Proteins
- Gene Dosage
- Genes, Fungal
- Genes, Lethal
- Immunosuppressive Agents
- Isoxazoles
- Leflunomide
- Membrane Transport Proteins
- Mutation
- Nucleotide Transport Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Uracil