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Article

Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast.

Molecular microbiology - 1 Mar 2004

Dieckhoff Patrick, Bolte Melanie, Sancak Yasemin, Braus Gerhard H, Irniger Stefan

Abstract excerpt

Ubiquitin-mediated proteolysis triggered by the anaphase-promoting complex/cyclosome (APC/C) is essential for sister chromatid separation and the mitotic exit. Like ubiquitylation, protein modification with the small ubiquitin-related modifier SUMO appears to be important during mitosis, because yeast cells impaired in the SUMO-conjugating enzyme Ubc9 were found to be blocked in mitosis and defective in cyclin...

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Source

Identifiers

PMID: 14982631
DOI: 10.1046/j.1365-2958.2003.03910.x

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast.PMID 14982631Read ↗

SUMO targets the APC/C to regulate transition from metaphase to anaphaseSemantic proximity Read ↗

Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.Semantic proximity Read ↗

In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.Semantic proximity Read ↗

Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation.Semantic proximity Read ↗

An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

The role of SUMO in chromosome segregation.Semantic proximity Read ↗

UBC9 autosumoylation negatively regulates sumoylation of septins in Saccharomyces cerevisiae.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation.Semantic proximity Read ↗

Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.Semantic proximity Read ↗

Role of SUMO in the dynamics of telomere maintenance in fission yeast.Semantic proximity Read ↗

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