Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models.

BMC structural biology - 6 May 2013

Honorat Mylène, Terreux Raphaël, Falson Pierre, Di Pietro Attilio, Dumontet Charles, Payen Lea

Abstract excerpt

BACKGROUND: The Multidrug Resistance Protein ABCC11/MRP8 is expressed in physiological barriers and tumor breast tissues in which it secretes various substrates including cGMP (cyclic guanosine monophosphate) and 5FdUMP (5-fluoro-2'-deoxyuridine-5'-monophosphate), the active metabolite of the anticancer drug 5-FluoroUracil (frequently included to anticancer therapy).Previously, we described that ABCC11 high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Cyclic GMP

Share to Databases, Protein

Share to Molecular Dynamics Simulation

Share to Sequence Alignment

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 23641929
DOI: 10.1186/1472-6807-13-7
PMCID: PMC3668285

Genes

ABCC11
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models.PMID 23641929Read ↗

The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations.Semantic proximity Read ↗

Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporterSemantic proximity Read ↗

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.Semantic proximity Read ↗

The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression.Semantic proximity Read ↗

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structureSemantic proximity Read ↗

3d Pharamacophore Model, Virtual Screening, Binding Affinity and Molecular Dynamics Studies of Potential Anticancerous Compounds Against Mammalian Target RapamycinSemantic proximity Read ↗

Multidrug efflux pumps: The structures of prokaryotic ATP‐binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P‐glycoproteins and homologuesSemantic proximity Read ↗

Tracing the substrate translocation mechanism in P-glycoprotein.Semantic proximity Read ↗

Tracing the substrate translocation mechanism in P-glycoproteinSemantic proximity Read ↗

Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter.Semantic proximity Read ↗

Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model.Semantic proximity Read ↗

Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.