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Article

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

4 Sept 2009

Abstract excerpt

The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of Escherichia coli MsbA, which were constructed in order to elucidate differences in the electrostatic and molecular features of their drug recognition conformations....

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PMID: 19732422
DOI: 10.1186/1742-4682-6-20

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