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Article

Lamin aggregation is an early sensor of porphyria-induced liver injury.

Journal of cell science - 15 Jul 2013

Singla Amika, Griggs Nicholas W, Kwan Raymond, Snider Natasha T, Maitra Dhiman, Ernst Stephen A, Herrmann Harald, Omary M Bishr

Abstract excerpt

Oxidative liver injury during steatohepatitis results in aggregation and transglutaminase-2 (TG2)-mediated crosslinking of the keratin cytoplasmic intermediate filament proteins (IFs) to form Mallory-Denk body (MDB) inclusions. The effect of liver injury on lamin nuclear IFs is unknown, though lamin mutations in several human diseases result in lamin disorganization and nuclear shape changes. We tested the...

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Identifiers

PMID: 23641075
DOI: 10.1242/jcs.123026
PMCID: PMC3711202

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lamin aggregation is an early sensor of porphyria-induced liver injury.PMID 23641075Read ↗

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