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Article

A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2016

Elenbaas Jared S, Maitra Dhiman, Liu Yang, Lentz Stephen I, Nelson Bradley, Hoenerhoff Mark J, Shavit Jordan A, Omary M Bishr

Abstract excerpt

Protoporphyria is a metabolic disease that causes excess production of protoporphyrin IX (PP-IX), the final biosynthetic precursor to heme. Hepatic PP-IX accumulation may lead to end-stage liver disease. We tested the hypothesis that systemic administration of porphyrin precursors to zebrafish larvae results in protoporphyrin accumulation and a reproducible nongenetic porphyria model. Retro-orbital infusion of...

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Identifiers

PMID: 26839379
DOI: 10.1096/fj.201500111R
PMCID: PMC4836371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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