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Article

Tumor Suppressors Status in Cancer Cell Line Encyclopedia

11 Apr 2013

Abstract excerpt

Tumor suppressors play a major role in the etiology of human cancer, and typically achieve a tumor-promoting effect upon complete functional inactivation. Bi-allelic inactivation of tumor suppressors may occur through genetic mechanisms (such as loss of function mutation, copy number (CN) loss, or loss of heterozygosity (LOH)), epigenetic mechanisms (such as promoter methylation or histone modification), or a...

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PMID: 23639312
DOI: 10.1016/j.molonc.2013.04.001

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