Article
Pitfalls in experimental designs for characterizing the transcriptional, methylational and copy number changes of oncogenes and tumor suppressor genes.
PloS one - 1 Jan 2013
Zhang Yuannv, Xia Jiguang, Zhang Yujing, Qin Yao, Yang Da, Qi Lishuang, Zhao Wenyuan, Wang Chenguang, Guo Zheng
Abstract excerpt
BACKGROUND: It is a common practice that researchers collect a set of samples without discriminating the mutants and their wild-type counterparts to characterize the transcriptional, methylational and/or copy number changes of pre-defined candidate oncogenes or tumor suppressor genes (TSGs), although some examples are known that carcinogenic mutants may express and function completely differently from their...
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