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Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

15 Jan 2019

Abstract excerpt

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-rich strand in yeast and human cells. Cells sense telomere length shortening and respond with...

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PMID: 30650660
DOI: 10.3390/cells8010054

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