Vaccines, reverse vaccinology, and bacterial pathogenesis.

Abstract excerpt

Advances in genomics and innovative strategies such as reverse vaccinology have changed the concepts and approaches to vaccine candidate selection and design. Genome mining and blind selection of novel antigens provide a novel route to investigate the mechanisms that underpin pathogenesis. The resulting lists of novel candidates are revealing new aspects of pathogenesis of target organisms, which in turn drives...

Topics

• Animals
• Antigens, Bacterial
• Bacterial Proteins
• Bacterial Typing Techniques
• Disease Models, Animal
• Drug Design
• Forecasting
• Genetic Predisposition to Disease
• Genome, Bacterial
• Genomics
• Humans
• Meningococcal Infections
• Meningococcal Vaccines
• Neisseria meningitidis
• Polymorphism, Single Nucleotide