Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations.

European journal of endocrinology - 1 Jul 2013

Zgaga Lina, Vitart Veronique, Hayward Caroline, Kastelan Darko, Polasek Ozren, Jakovljevic Miro, Kolcic Ivana, Biloglav Zrinka, Wright Alan F, Campbell Harry, Walker Brian R, Rudan Igor

Abstract excerpt

OBJECTIVE: Stress is implicated as a risk factor for numerous illnesses in humans, putatively in part mediated by biological responses to stress, such as elevated cortisol concentrations. The theory of genetic homoeostasis suggests that individual heterozygosity facilitates compensation for environmental stresses. We hypothesized that heterozygosity ameliorates the biological response to a given level of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Croatia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Educational Status

Share to Genetic Carrier Screening

Share to Hydrocortisone

Share to Socioeconomic Factors

Share to Stress, Psychological

Share to Surveys and Questionnaires

Source

Identifiers

PMID: 23636447
DOI: 10.1530/EJE-12-0916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations.PMID 23636447Read ↗

Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits.Semantic proximity Read ↗

Genetic diversity is a predictor of mortality in humans.Semantic proximity Read ↗

Effects of isolation and inbreeding on human quantitative traits: an example of biochemical markers of hemostasis and inflammation.Semantic proximity Read ↗

The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels.Semantic proximity Read ↗

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.Semantic proximity Read ↗

Heterozygosity Ratio, a Robust Global Genomic Measure of Autozygosity and Its Association with Height and Disease Risk.Semantic proximity Read ↗

Quantifying the increase in average human heterozygosity due to urbanisation.Semantic proximity Read ↗

Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study.Semantic proximity Read ↗

Multilocus heterozygosity and coronary heart disease: nested case-control studies in men and women.Semantic proximity Read ↗

Does genetic diversity predict health in humans?Semantic proximity Read ↗

Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement.Semantic proximity Read ↗

Single nucleotide polymorphisms related to HPA axis reactivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.