Article
Quantifying the increase in average human heterozygosity due to urbanisation.
European journal of human genetics : EJHG - 1 Sept 2008
Rudan Igor, Carothers Andrew D, Polasek Ozren, Hayward Caroline, Vitart Veronique, Biloglav Zrinka, Kolcic Ivana, Zgaga Lina, Ivankovic Davor, Vorko-Jovic Ariana, Wilson James F, Weber James L, Hastie Nick, Wright Alan, Campbell Harry
Abstract excerpt
The human population is undergoing a major transition from a historical metapopulation structure of relatively isolated small communities to an outbred structure. This process is predicted to increase average individual genome-wide heterozygosity (h) and could have effects on health. We attempted to quantify this increase in mean h. We initially sampled 1001 examinees from a metapopulation of nine isolated...
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