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Article

Endothelial Responses in Sepsis.

American journal of respiratory and critical care medicine - 1 Aug 2020

Joffre Jérémie, Hellman Judith, Ince Can, Ait-Oufella Hafid

Abstract excerpt

Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in the systemic response after bacterial infection to limit its dissemination. Triggered by exposure to pathogens, microbial toxins, or endogenous danger signals, EC responses are polymorphous, heterogeneous, and multifaceted. During sepsis, ECs shift toward a proapoptotic, proinflammatory, proadhesive, and procoagulant...

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PMID: 32101446
DOI: 10.1164/rccm.201910-1911TR

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