Article

The Immunophilin Protein FKBPL and its Peptide Derivatives are Novel Regulators of Vascular Integrity and Inflammation via Nf-κB Signaling

2021-06-01

Abstract excerpt

A breakdown in vascular integrity and excessive inflammation are hallmarks of serious pathological conditions including sepsis, acute respiratory distress syndrome (ARDs) and most recently, severe COVID-19. FK506 binding protein like (FKBPL) is a member of the immunophilin protein superfamily with potent anti tumor activity through inhibition of angiogenesis and cancer stemness. An FKBPL based 23mer peptide, ALM20...

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Literature Corpus work: 4b1266b0-f91b-56b3-b3f2-9c02e7264a58
DOI: 10.2139/ssrn.3858052

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