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Article

Lipopolysaccharide exposure modulates the contractile and migratory phenotypes of vascular smooth muscle cells.

Life sciences - 15 Jan 2020

Strela Felipe Bichi, Brun Bruna Ferro, Berger Rebeca Caldeira Machado, Melo Stephano, de Oliveira Edilamar Menezes, Barauna Valério Garrone, Vassallo Paula Frizera

Abstract excerpt

INTRODUCTION: Sepsis survivors are at higher risk for cardiovascular events. Lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4) in sepsis. Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis. AIM: Investigate changes in VSMCs phenotype caused by LPS-induced TLR4 activation. METHODS: Rat VSMCs were incubated with LPS. Two...

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Identifiers

PMID: 31794773
DOI: 10.1016/j.lfs.2019.117098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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