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Article

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis.

Critical care (London, England) - 4 Oct 2012

Alfieri Alessio, Watson Jay J, Kammerer Richard A, Tasab Mohammed, Progias Pavlos, Reeves Kimberly, Brown Nicola J, Brookes Zoe L

Abstract excerpt

INTRODUCTION: Severe sepsis is characterised by intravascular or extravascular infection with microbial agents, systemic inflammation and microcirculatory dysfunction, leading to tissue damage, organ failure and death. The growth factor angiopoietin (Ang-1) has therapeutic potential but recombinant Ang-1 tends to aggregate and has a short half-life in vivo. This study aimed to investigate the acute effects of the...

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Identifiers

PMID: 23036162
DOI: 10.1186/cc11666
PMCID: PMC3682284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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