Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.

Acta neuropathologica - 1 Dec 2010

Tatevossian Ruth G, Tang Bo, Dalton James, Forshew Tim, Lawson Andrew R, Ma Jing, Neale Geoff, Shurtleff Sheila A, Bailey Simon, Gajjar Amar, Baker Suzanne J, Sheer Denise, Ellison David W

Abstract excerpt

Recent studies of genetic abnormalities in pediatric low-grade gliomas (LGGs) have focused on activation of the ERK/MAPK pathway by KIAA1549-BRAF gene fusions in the majority of pilocytic astrocytomas (PAs) and by rare mutations in elements of the pathway across histopathologically diverse LGGs....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Age Factors
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to Gene Amplification

Share to Gene Deletion

Share to Glioma

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 21046410
DOI: 10.1007/s00401-010-0763-1
PMCID: PMC3066475

Genes

MYB
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21046410-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.PMID 21046410Read ↗

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Semantic proximity Read ↗

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.Semantic proximity Read ↗

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.Semantic proximity Read ↗

New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model.Semantic proximity Read ↗

MYB/MYBL1::QKI fusion-positive diffuse glioma.Semantic proximity Read ↗

Comprehensive analysis of MYB/MYBL1 -altered pediatric-type diffuse low-grade gliomaSemantic proximity Read ↗

MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genesSemantic proximity Read ↗

MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2Semantic proximity Read ↗

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Semantic proximity Read ↗

Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade Gliomas.Semantic proximity Read ↗

Histological Anaplasia and Chromosome 6 Chromothripsis as Predictive Factors of Aggressivity in Low-grade Glioma, MYB/MYBL1-AlteredSemantic proximity Read ↗

Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.