Article
Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application.
PloS one - 1 Jan 2013
Geyeregger René, Freimüller Christine, Stevanovic Stefan, Stemberger Julia, Mester Gabor, Dmytrus Jasmin, Lion Thomas, Rammensee Hans-Georg, Fischer Gottfried, Eiz-Vesper Britta, Lawitschka Anita, Matthes Susanne, Fritsch Gerhard
Abstract excerpt
Adenoviral infections are a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients. Adoptive transfer of donor-derived human adenovirus (HAdV)-specific T-cells represents a promising treatment option. However, the difficulty in identifying and selecting rare HAdV-specific T-cells, and the short time span between patients at high risk for...
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