Article
Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.
Blood - 19 Mar 2015
Feucht Judith, Opherk Kathrin, Lang Peter, Kayser Simone, Hartl Lena, Bethge Wolfgang, Matthes-Martin Susanne, Bader Peter, Albert Michael H, Maecker-Kolhoff Britta, Greil Johann, Einsele Hermann, Schlegel Paul-Gerhardt, Schuster Friedhelm R, Kremens Bernhard, Rossig Claudia, Gruhn Bernd, Handgretinger Rupert, Feuchtinger Tobias
Abstract excerpt
Hematopoietic stem cell transplantation (HSCT) has improved over the last few decades. However, viral infections are often refractory to pharmacologic treatment and require alternative treatment strategies such as immunotherapy. Adenovirus (AdV) is th predominant disease-causing pathogen in pediatric HSCT. In a clinical trial, we analyzed safety and efficacy of ex vivo adoptive T-cell transfer (ACT) with...
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