Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue.

PloS one - 1 Jan 2011

Joshi Amita, Zhao Biwei, Romanowski Cara, Rosen David, Flomenberg Phyllis

Abstract excerpt

Treatment of invasive adenovirus (Ad) disease in hematopoietic stem cell transplant (SCT) recipients with capsid protein hexon-specific donor T cells is under investigation. We propose that cytotoxic T cells (CTLs) targeted to the late protein hexon may be inefficient in vivo because the early Ad protein E3-19K downregulates HLA class I antigens in infected cells. In this study, CD8+ T cells targeted to highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenovirus Early Proteins
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to DNA-Directed DNA Polymerase

Share to Epitopes

Share to Immunologic Memory

Share to Palatine Tonsil

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 21637763
DOI: 10.1371/journal.pone.0020068
PMCID: PMC3103520

Genes

SCT
TNF
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue.PMID 21637763Read ↗

The Adenovirus Capsid Protein Hexon Contains a Highly Conserved Human CD4 + T-Cell EpitopeSemantic proximity Read ↗

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection.Semantic proximity Read ↗

Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and ImmunotherapySemantic proximity Read ↗

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes.Semantic proximity Read ↗

The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon proteinSemantic proximity Read ↗

Adenovirus-Specific CD4+ T Cell Clones Recognizing Endogenous Antigen Inhibit Viral Replication In Vitro through Cognate InteractionSemantic proximity Read ↗

Human CD4<sup>+</sup> T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirusSemantic proximity Read ↗

Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application.Semantic proximity Read ↗

Induction of Thelper1-driven antiviral T-cell lines for adoptive immunotherapy is determined by differential expression of IFN-γ and T-cell activation markers.Semantic proximity Read ↗

Establishment and Operation of a Third-Party Virus-Specific T Cell Bank within an Allogeneic Stem Cell Transplant ProgramSemantic proximity Read ↗

Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells.Semantic proximity Read ↗

Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II alleleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.