Article
The RNAsnp web server: predicting SNP effects on local RNA secondary structure.
Nucleic acids research - 1 Jul 2013
Sabarinathan Radhakrishnan, Tafer Hakim, Seemann Stefan E, Hofacker Ivo L, Stadler Peter F, Gorodkin Jan
Abstract excerpt
The function of many non-coding RNA genes and cis-regulatory elements of messenger RNA largely depends on the structure, which is in turn determined by their sequence. Single nucleotide polymorphisms (SNPs) and other mutations may disrupt the RNA structure, interfere with the molecular function and hence cause a phenotypic effect. RNAsnp is an efficient method to predict the effect of SNPs on local RNA secondary...
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