Article
mrSNP: software to detect SNP effects on microRNA binding.
BMC bioinformatics - 15 Mar 2014
Deveci Mehmet, Catalyürek Umit V, Toland Amanda Ewart
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) are short (19-23 nucleotides) non-coding RNAs that bind to sites in the 3'untranslated regions (3'UTR) of a targeted messenger RNA (mRNA). Binding leads to degradation of the transcript or blocked translation resulting in decreased expression of the targeted gene. Single nucleotide polymorphisms (SNPs) have been found in 3'UTRs that disrupt normal miRNA binding or introduce new...
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