Article
RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins.
Nucleic acids research - 4 Jan 2016
Mao Fengbiao, Xiao Luoyuan, Li Xianfeng, Liang Jialong, Teng Huajing, Cai Wanshi, Sun Zhong Sheng
Abstract excerpt
Transcription factors bind to the genome by forming specific contacts with the primary DNA sequence; however, RNA-binding proteins (RBPs) have greater scope to achieve binding specificity through the RNA secondary structure. It has been revealed that single nucleotide variants (SNVs) that alter RNA structure, also known as RiboSNitches, exhibit 3-fold greater local structure changes than replicates of the same...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.