Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy facilitates cytokine-induced ICAM-1 expression.

Innate immunity - 1 Feb 2014

Wang Chi-Yun, Chiang Tzu-Hui, Chen Chia-Ling, Tseng Po-Chun, Chien Shun-Yi, Chuang Yi-Jui, Yang Tsan-Tzu, Hsieh Chia-Yuan, Choi Pui-Ching, Lin Chiou-Feng

Abstract excerpt

ICAM-1 can be induced by inflammatory cytokines such as IFN-γ and TNF-α. This study investigated whether autophagy regulates ICAM-1 given that autophagy facilitates signaling of these two cytokines. Exogenous IFN-γ induced ICAM-1 in human lung epithelial A549 cells carrying wild type p53, a transcription factor reported for ICAM-1, but not in PC14PE6/AS2 (AS2) cells carrying mutated p53. However, IFN-γ also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Intercellular Adhesion Molecule-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Mice, Nude

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Proto-Oncogene Proteins c-bcl-2

Share to Respiratory Mucosa

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 23751820
DOI: 10.1177/1753425913488227

Genes

TNF
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy facilitates cytokine-induced ICAM-1 expression.PMID 23751820Read ↗

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shockSemantic proximity Read ↗

Type I interferons induce autophagy in certain human cancer cell linesSemantic proximity Read ↗

Interferon-gamma-induced epithelial ICAM-1 expression and monocyte adhesion. Involvement of protein kinase C-dependent c-Src tyrosine kinase activation pathway.Semantic proximity Read ↗

Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cellsSemantic proximity Read ↗

A Death-Promoting Role for ISG54/IFIT2Semantic proximity Read ↗

The Interferon Stimulated Gene 54 Promotes ApoptosisSemantic proximity Read ↗

c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression.Semantic proximity Read ↗

Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway.Semantic proximity Read ↗

Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia-reperfusion injury via the P38/P62 pathway in mice.Semantic proximity Read ↗

miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes.Semantic proximity Read ↗

A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis.Semantic proximity Read ↗

Stat1-Dependent, p53-Independent Expression of p21 waf1 Modulates Oxysterol-Induced ApoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.