Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

doi:10.1371/journal.pgen.1002505

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Article

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

PLoS genetics - 1 Jan 2012

Min Josine L, Nicholson George, Halgrimsdottir Ingileif, Almstrup Kristian, Petri Andreas, Barrett Amy, Travers Mary, Rayner Nigel W, Mägi Reedik, Pettersson Fredrik H, Broxholme John, Neville Matt J, Wills Quin F, Cheeseman Jane, Allen Maxine, Holmes Chris C, Spector Tim D, Fleckner Jan, McCarthy Mark I, Karpe Fredrik, Lindgren Cecilia M, Zondervan Krina T

Abstract excerpt

Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abdominal (ABD) and gluteal (GLU) adipose tissue, and whole blood (WB), from 29 MetS cases and 44 controls. Co-expression network analysis for each tissue independently...

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PMID: 22383892
DOI: 10.1371/journal.pgen.1002505
PMCID: PMC3285582

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