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Article

Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.

The Laryngoscope - 1 Jun 2013

Xie Tong-Xin, Zhou Ge, Zhao Mei, Sano Daisuke, Jasser Samar A, Brennan Richard G, Myers Jeffrey N

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Mutation of the TP53 gene occurs in more than half of cases of head and neck squamous cell carcinoma (HNSCC). However, little is known about how specific TP53 mutations affect tumor progression. The objective of this study is to determine the gain of function of mutant p53...

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Share to Carcinoma, Squamous Cell
Share to DNA, Neoplasm
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Experimental

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Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 23625637
DOI: 10.1002/lary.23846
PMCID: PMC3664100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23625637-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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