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Article

Defining the critical roles of factor VIII residues 1900 to 1908 in factor VIIIa-factor IXa complex formation and factor VIIIa activity.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2026

Lv Haixia, Ming Zhe, Wang Dongmei, Jin Mei, Li Wenqiang, Wang Wensheng

Abstract excerpt

BACKGROUND: Factor (F)VIIIa acts as a cofactor with FIXa on phospholipid surfaces to convert FX to FXa. Region 1900 to 1908 is a known FVIIIa antibody epitope, with mutations in this region linked to hemophilia A. However, its role in FXase activity is unclear. This study investigates how individual residues within 1900 and 1908 affect interprotein affinity and cofactor activity. OBJECTIVES: This study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41407158
DOI: 10.1016/j.jtha.2025.12.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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