Article
Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.
The Journal of biological chemistry - 15 Feb 1990
Bajaj S P, Spitzer S G, Welsh W J, Warn-Cramer B J, Kasper C K, Birktoft J J
Abstract excerpt
Factor IX is the zymogen of the serine protease factor IXa involved in blood coagulation. In addition to a catalytic domain homologous to the chymotrypsin family, it has Ca2+, phospholipid, and factor VIIIa binding regions needed for full biologic activity. We isolated a nonfunctional factor IX p...
Topics
- Computer Graphics
- Enzyme Activation
- Enzyme Precursors
- Factor IXa
- Factor X
- Glycine
- Hemophilia A
- Humans
- Models, Molecular
- Mutation
- Polymerase Chain Reaction
- Protein Conformation