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Article

DNA damage repair and tolerance: a role in chemotherapeutic drug resistance

1 Jan 2013

Abstract excerpt

A significant barrier to effective cancer therapy is the development of resistance to the drugs utilised. Standard chemotherapeutic regimens typically contain genotoxic agents, designed to damage DNA of existing tumour cells as well as prevent the synthesis of new DNA during proliferation. DNA damage in normal cells can be repaired efficiently or tolerated to preserve cellular and organ functionality. The...

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Identifiers

PMID: 23617096
DOI: 10.1080/09674845.2013.11669927

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