Cancer, DNA Repair Mechanisms, and Resistance to Chemotherapy

Abstract excerpt

Soon after the introduction of daunomycin and cytosine arabinoside (i.e., cytarabine) in the early 1960's, several reports appeared examining the effects of these agents on bone marrow and peripheral blood cells (1,2). A surprisingly high percentage of normal cells, as many as 92% in some patients treated with daunomycin, had gross chromosomal damage. As we look back on these early studies, it is clear that a...

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