Article
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
Science translational medicine - 10 Jan 2018
Hui Ken Y, Fernandez-Hernandez Heriberto, Hu Jianzhong, Schaffner Adam, Pankratz Nathan, Hsu Nai-Yun, Chuang Ling-Shiang, Carmi Shai, Villaverde Nicole, Li Xianting, Rivas Manual, Levine Adam P, Bao Xiuliang, Labrias Philippe R, Haritunians Talin, Ruane Darren, Gettler Kyle, Chen Ernie, Li Dalin, Schiff Elena R, Pontikos Nikolas, Barzilai Nir, Brant Steven R, Bressman Susan, Cheifetz Adam S, Clark Lorraine N, Daly Mark J, Desnick Robert J, Duerr Richard H, Katz Seymour, Lencz Todd, Myers Richard H, Ostrer Harry, Ozelius Laurie, Payami Haydeh, Peter Yakov, Rioux John D, Segal Anthony W, Scott William K, Silverberg Mark S, Vance Jeffery M, Ubarretxena-Belandia Iban, Foroud Tatiana, Atzmon Gil, Pe'er Itsik, Ioannou Yiannis, McGovern Dermot P B, Yue Zhenyu, Schadt Eric E, Cho Judy H, Peter Inga
Abstract excerpt
Crohn's disease (CD), a form of inflammatory bowel disease, has a higher prevalence in Ashkenazi Jewish than in non-Jewish European populations. To define the role of nonsynonymous mutations, we performed exome sequencing of Ashkenazi Jewish patients with CD, followed by array-based genotyping and association analysis in 2066 CD cases and 3633 healthy controls. We detected association signals in the LRRK2 gene...
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