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Article

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense.

The EMBO journal - 15 Oct 1997

Williams M J, Rodriguez A, Kimbrell D A, Eldon E D

Abstract excerpt

Mammals and insects employ similar Rel/NF-kappaB signaling cascades in their humoral immune responses. The mammalian interleukin-1 type I receptor (IL-1R) is one way of activating this cascade. The Drosophila Toll protein, whose cytoplasmic domain shows striking similarity to that of the IL-1R, acts in the humoral antimicrobial response. Here we demonstrate that a second IL-1R-related Drosophila protein,...

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Identifiers

PMID: 9321392
DOI: 10.1093/emboj/16.20.6120
PMCID: PMC1326296

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