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Article

Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila.

PLoS biology - 1 Jan 2022

van Alphen Bart, Stewart Samuel, Iwanaszko Marta, Xu Fangke, Li Keyin, Rozenfeld Sydney, Ramakrishnan Anujaianthi, Itoh Taichi Q, Sisobhan Shiju, Qin Zuoheng, Lear Bridget C, Allada Ravi

Abstract excerpt

In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo remain to be elucidated. To address this question, we developed a Drosophila head-specific model for TBI termed Drosophila Closed Head Injury (dCHI), where well-controlled, nonpenetrating strikes are delivered to the head of...

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Identifiers

PMID: 35081110
DOI: 10.1371/journal.pbio.3001456
PMCID: PMC8791498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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