Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoid metabolism and reproduction: a tale of two enzymes

1 Oct 2003

Abstract excerpt

Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Hormonal Regulation and Hypertension
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14525525
DOI: 10.1530/rep.0.1260425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid metabolism and reproduction: a tale of two enzymesPMID 14525525Read ↗

11 beta-Hydroxysteroid dehydrogenase.Semantic proximity Read ↗

Dual Function of 11β-Hydroxysteroid Dehydrogenase in Placenta: Modulating Placental Glucocorticoid Passage and Local Steroid Action1Semantic proximity Read ↗

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progressSemantic proximity Read ↗

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.Semantic proximity Read ↗

[11 beta-hydroxysteroid-dehydrogenase: characteristics and the clinical significance of a key enzyme in cortisol metabolism].Semantic proximity Read ↗

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.Semantic proximity Read ↗

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveriesSemantic proximity Read ↗

Deciphering the Dichotomy: The Role of Glucocorticoid Receptor Isoforms in Cortisol’s Paradoxical Impact on Reproduction and PregnancySemantic proximity Read ↗

[11beta-hydroxysteroide dehydrogenases. Recent advances].Semantic proximity Read ↗

Foetal and placental 11<i>β</i>‐<scp>HSD</scp>2: a hub for developmental programmingSemantic proximity Read ↗

Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal developmentSemantic proximity Read ↗

Glucocorticoid ProgrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.