Article
No evidence for association of the CD40, CD40L and BLYS polymorphisms, B-cell co-stimulatory molecules, with Brazilian endemic Plasmodium vivax malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jun 2013
Capobianco Marcela P, Cassiano Gustavo C, Furini Adriana A C, Storti-Melo Luciane M, Pavarino Erika C, Galbiatti Ana L S, Fraga Valéria D, Conceição Luciana M, Couto Vanja S C, Couto Alvaro A R A, Machado Ricardo L D
Abstract excerpt
BACKGROUND: Plasmodium vivax is the most prevalent malaria species in Brazil. The parasite-host coevolutionary process can be viewed as an 'arms race', in which adaptive genetic changes in one are eventually matched by alterations in the other. METHODS: Following the candidate gene approach we analyzed the CD40, CD40L and BLYS genes that participate in B-cell co-stimulation, for associations with P. vivax...
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