No Evidence for Association Between ICOS (a T-Cell Co-Stimulatory Molecule) Gene Polymorphisms and Anti-MSP-119 IgG Response in Venezuelan Endemic Plasmodium vivax Malaria.

Abstract excerpt

The blood-stage merozoite surface protein 1 (PvMSP19) of Plasmodium vivax is a key target of naturally acquired antibodies. Effective humoral responses depend on T-cell co-stimulation, notably via the inducible co-stimulator (ICOS) molecule. Polymorphisms in the ICOS gene may influence antibody production, yet this relationship remains unexplored in naturally infected populations. We analysed 91 individuals with...

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