Article
Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.
American journal of hematology - 1 Jan 2024
Hong Hyokyoung G, Gouveia Mateus H, Ogwang Martin D, Kerchan Patrick, Reynolds Steven J, Tenge Constance N, Were Pamela A, Kuremu Robert T, Wekesa Walter N, Masalu Nestory, Kawira Esther, Kinyera Tobias, Wang Xunde, Zhou Jiefu, Leal Thiago Peixoto, Otim Isaac, Legason Ismail D, Nabalende Hadijah, Dhudha Herry, Mumia Mediatrix, Baker Francine S, Okusolubo Temiloluwa, Ayers Leona W, Bhatia Kishor, Goedert James J, Woo Joshua, Manning Michelle, Cole Nathan, Luo Wen, Hicks Belynda, Chagaluka George, Johnston W Thomas, Mutalima Nora, Borgstein Eric, Liomba George N, Kamiza Steve, Mkandawire Nyengo, Mitambo Collins, Molyneux Elizabeth M, Newton Robert, Hutchinson Amy, Yeager Meredith, Adeyemo Adebowale A, Thein Swee Lay, Rotimi Charles N, Chanock Stephen J, Prokunina-Olsson Ludmila, Mbulaiteye Sam M
Abstract excerpt
Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that significantly contributes to childhood cancer burden in sub-Saharan Africa. Plasmodium falciparum, which causes malaria, is geographically associated with BL, but the evidence remains insufficient for causal inference. Inference could be strengthened by demonstrating that mendelian genes known to protect against malaria-such as the sickle cell trait...
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