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Article

Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009

Gao Guanjun, Bi Xiaolin, Chen Jie, Srikanta Deepa, Rong Yikang S

Abstract excerpt

Using Drosophila as a model system, we identified here a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development. Animals homozygous for hypomorphic mutations in either mre11 or nbs develop normally with minimal telomere dysfunction. However, they produce inviable embryos that succumb to failure of mitosis caused by covalent fusion of telomeric DNA....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19520832
DOI: 10.1073/pnas.0902707106
PMCID: PMC2705596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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