Article
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Nature genetics - 1 Jun 2013
Hinks Anne, Cobb Joanna, Marion Miranda C, Prahalad Sampath, Sudman Marc, Bowes John, Martin Paul, Comeau Mary E, Sajuthi Satria, Andrews Robert, Brown Milton, Chen Wei-Min, Concannon Patrick, Deloukas Panos, Edkins Sarah, Eyre Stephen, Gaffney Patrick M, Guthery Stephen L, Guthridge Joel M, Hunt Sarah E, James Judith A, Keddache Mehdi, Moser Kathy L, Nigrovic Peter A, Onengut-Gumuscu Suna, Onslow Mitchell L, Rosé Carlos D, Rich Stephen S, Steel Kathryn J A, Wakeland Edward K, Wallace Carol A, Wedderburn Lucy R, Woo Patricia, Bohnsack John F, Haas Johannes Peter, Glass David N, Langefeld Carl D, Thomson Wendy, Thompson Susan D
Abstract excerpt
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis (JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor-negative polyarticular JIA), and 13,056 controls. We confirmed association of 3 known JIA risk loci (the human leukocyte antigen (HLA) region, PTPN22 and PTPN2) and identified 14 loci reaching genome-wide significance (P < 5 × 10(-8)) for the...
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