Article
Genetic variants in interleukin-18 gene and risk for cervical squamous cell carcinoma.
Human immunology - 1 Jul 2013
Yang Yuh-Cheng, Chang Tzu-Yang, Chen Tze-Chien, Chang Shih-Chuan, Lin Wen-Shan, Lee Yann-Jinn
Abstract excerpt
Cervical cancer is strongly associated with infection of oncogenic types of human papillomavirus (HPV). However, HPV infection alone is not sufficient for progression to cervical cancer. It is now recognized that host immunogenetic background participates in the control of HPV infection and development of cervical cancer. Interleukin-18 (IL-18) is a multifunctional cytokine that induces interferon-gamma secretion...
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