Article
CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women.
Carcinogenesis - 1 Jun 2007
Su Tsung-Hsien, Chang Tzu-Yang, Lee Yann-Jinn, Chen Chih-Kai, Liu Hsin-Fu, Chu Chen-Chung, Lin Marie, Wang Pu-Tsui, Huang Wen-Chu, Chen Tze-Chien, Yang Yuh-Cheng
Abstract excerpt
Human papillomavirus (HPV) is considered to be a necessary but not sufficient cause for cervical cancer. The host immunogenetic background plays an important role in the persistence of HPV infection and subsequent development of cervical cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed mainly on activated T cells and is important in the down-regulation of T-cell activation. The aim of...
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