Pyoverdine, a siderophore from Pseudomonas aeruginosa , translocates into C. elegans , removes iron, and activates a distinct host response

Abstract excerpt

Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and...

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