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Article

Expression of the PXR gene in various types of cancer and drug resistance

22 Jan 2013

Abstract excerpt

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of...

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PMID: 23599746
DOI: 10.3892/ol.2013.1149

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